diltiazem

dil-TYE-a-zem

Commonly used brand name(s)

In the U.S.

• Cardizem


• Cardizem CD


• Cardizem LA


• Cartia XT


• Dilacor XR


• Dilt-CD


• Diltia XT


• Dilt-XR


• Diltzac


• Matzim LA


• Taztia XT


• Tiazac

Available Dosage Forms:

• Capsule, Extended Release


• Tablet, Extended Release


• Tablet


• Capsule, Extended Release, 24 HR


• Capsule, Extended Release, 12 HR

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Benzothiazepine

Uses For diltiazem

Diltiazem is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Diltiazem is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, diltiazem relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

diltiazem is available only with your doctor's prescription .

Before Using diltiazem

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For diltiazem, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to diltiazem or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of diltiazem in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of diltiazem in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require an adjustment in the dose for patients receiving diltiazem .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking diltiazem, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using diltiazem with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride

Using diltiazem with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alprenolol


• Amiodarone


• Aprepitant


• Atazanavir


• Atenolol


• Atorvastatin


• Betaxolol


• Bevantolol


• Bisoprolol


• Bucindolol


• Carteolol


• Carvedilol


• Celiprolol


• Clonidine


• Clozapine


• Colchicine


• Crizotinib


• Dantrolene


• Dilevalol


• Dronedarone


• Droperidol


• Erythromycin


• Esmolol


• Everolimus


• Fentanyl


• Labetalol


• Levobunolol


• Lurasidone


• Mepindolol


• Metipranolol


• Metoprolol


• Nadolol


• Nebivolol


• Oxprenolol


• Penbutolol


• Pindolol


• Propranolol


• Ranolazine


• Simvastatin


• Sotalol


• Talinolol


• Tertatolol


• Timolol


• Tolvaptan

Using diltiazem with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Alfuzosin


• Amlodipine


• Aspirin


• Buspirone


• Carbamazepine


• Celecoxib


• Cilostazol


• Cimetidine


• Clopidogrel


• Colestipol


• Cyclosporine


• Dalfopristin


• Digitoxin


• Digoxin


• Dutasteride


• Efavirenz


• Enflurane


• Fosaprepitant


• Fosphenytoin


• Guggul


• Indinavir


• Lithium


• Lovastatin


• Methylprednisolone


• Midazolam


• Moricizine


• Nevirapine


• Nifedipine


• Phenytoin


• Quinupristin


• Rifampin


• Rifapentine


• Ritonavir


• Sirolimus


• St John's Wort


• Tacrolimus


• Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of diltiazem. Make sure you tell your doctor if you have any other medical problems, especially:

• Bowel blockage, severe or


• Congestive heart failure—Use with caution. May make this condition worse .

• Heart attack or


• Heart block (type of abnormal heart rhythm, can use if have a pacemaker that works properly) or


• Hypotension (low blood pressure), severe or


• Lung problem (e.g., pulmonary congestion) or


• Sick sinus syndrome (type of abnormal heart rhythm, can use if have a pacemaker that works properly)—Should not be used in patients with these conditions .

• Kidney disease or


• Liver disease—Use with caution. The effects of diltiazem may be increased because of slower removal from the body .

Proper Use of diltiazem

In addition to the use of diltiazem, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that diltiazem will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Swallow the extended-release tablet or extended-release capsule whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach .

Dosing

The dose of diltiazem will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of diltiazem. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For chest pain:
  
  • For oral dosage form (tablets):
    
    • Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—At first, 180 mg once a day either in the evening or in the morning. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 120 mg once a day in the morning. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

• For high blood pressure:
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—At first, 180 to 240 milligrams (mg) once a day either in the morning or at bedtime. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 180 to 240 mg once a day in the morning. Your doctor may increase your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of diltiazem, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using diltiazem

It is very important that your doctor check your progress at regular visits to make sure diltiazem is working properly and to check for unwanted effects .

Low blood pressure (hypotension) may occur while taking diltiazem. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness .

Check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem .

Serious skin reactions can occur with diltiazem. Check with your doctor right away if you have any of the following symptoms while taking diltiazem: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; itching; joint or muscle pain; red skin lesions, often with a purple center; skin rash; sore throat; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness .

diltiazem Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Body aches or pain


• congestion


• cough


• dryness or soreness of throat


• fever


• hoarseness


• runny nose


• tender or swollen glands in neck


• trouble in swallowing


• voice changes

Less common

• Chest pain or discomfort


• chills


• diarrhea


• difficult or labored breathing


• feeling faint, dizzy, or lightheaded


• feeling of warmth or heat


• flushing or redness of skin, especially on face and neck


• general feeling of discomfort or illness


• headache


• joint pain


• loss of appetite


• muscle aches and pains


• nausea


• shivering


• shortness of breath


• slow or irregular heartbeat


• sore throat


• sweating


• swelling of hands, ankles, feet, or lower legs


• tightness in chest


• trouble sleeping


• unusual tiredness or weakness


• vomiting


• wheezing

Incidence not known

• Blistering, peeling, or loosening of skin


• itching


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• no heart beat


• red irritated eyes


• red skin lesions, often with a purple center


• sores, ulcers, or white spots in mouth or on lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Sneezing


• stuffy nose

Less common

• Acid or sour stomach


• belching


• constipation


• continuing ringing or buzzing or other unexplained noise in ears


• degenerative disease of the joint


• difficulty in moving


• hearing loss


• heartburn


• indigestion


• lack or loss of strength


• muscle aching or cramping


• muscle pains or stiffness


• pain or tenderness around eyes and cheekbones


• rash


• sleeplessness


• stomach discomfort, upset, or pain


• swollen joints


• unable to sleep

Incidence not known

• Hair loss or thinning of hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: diltiazem side effects (in more detail)

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More diltiazem resources

• Diltiazem Side Effects (in more detail)
• Diltiazem Use in Pregnancy & Breastfeeding
• Drug Images
• Diltiazem Drug Interactions
• Diltiazem Support Group
• 31 Reviews for Diltiazem - Add your own review/rating

• Diltiazem MedFacts Consumer Leaflet (Wolters Kluwer)


• Diltiazem Prescribing Information (FDA)


• Cardizem Prescribing Information (FDA)


• Cardizem Consumer Overview


• Cardizem CD Prescribing Information (FDA)


• Cardizem CD 24-Hour Sustained-Release Beads Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Cardizem LA Prescribing Information (FDA)


• Cardizem LA 24-Hour Extended-Release Beads Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Cartia XT Prescribing Information (FDA)


• DILT-CD Prescribing Information (FDA)


• Dilacor XR 24-Hour Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Dilacor XR Prescribing Information (FDA)


• Dilt-XR Prescribing Information (FDA)


• Diltia XT Prescribing Information (FDA)


• Diltiazem Hydrochloride Monograph (AHFS DI)


• Matzim LA Prescribing Information (FDA)


• Taztia XT Prescribing Information (FDA)


• Taztia XT 24-Hour Extended-Release Beads Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Tiazac Prescribing Information (FDA)


• Tiazac Consumer Overview

Compare diltiazem with other medications

• Angina Pectoris Prophylaxis
• Atrial Fibrillation
• Atrial Flutter
• Heart Failure
• High Blood Pressure
• Raynaud's Syndrome
• Supraventricular Tachycardia

Dilacor XR 24-Hour Sustained-Release Capsules

Pronunciation: dil-TYE-a-zem
Generic Name: Diltiazem
Brand Name: Examples include Diltia XT and Dilt-XR

Dilacor XR 24-Hour Sustained-Release Capsules are used for:

Treating high blood pressure and chronic stable angina (chest pain). It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Dilacor XR 24-Hour Sustained-Release Capsules are a calcium channel blocker. It works by relaxing (dilating) your blood vessels, lowering blood pressure, and decreasing heart rate, which lowers the workload of the heart. It also dilates coronary arteries, which increases blood flow to the heart.

Do NOT use Dilacor XR 24-Hour Sustained-Release Capsules if:

• you are allergic to any ingredient in Dilacor XR 24-Hour Sustained-Release Capsules


• you have certain heart problems (eg, sick sinus syndrome, second- or third-degree heart block) and do not have a pacemaker, you have very low blood pressure, or you have fluid buildup in the lungs during or soon after a heart attack


• you are taking erythromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dilacor XR 24-Hour Sustained-Release Capsules:

Some medical conditions may interact with Dilacor XR 24-Hour Sustained-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart failure, a recent heart attack with lung congestion, heart block, a very slow heart rate, or other heart problems; low blood pressure; certain stomach or intestine problems (eg, narrowing); liver disease; or kidney problems


• if you are taking other medicines for high blood pressure or heart conditions

Some MEDICINES MAY INTERACT with Dilacor XR 24-Hour Sustained-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, dronedarone), cimetidine, clonidine, HIV protease inhibitors (eg, atazanavir, indinavir), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Dilacor XR 24-Hour Sustained-Release Capsules's side effects, such as heart rhythm problems


• Benzodiazepines (eg, alprazolam), beta-blockers (eg, propranolol), buspirone, carbamazepine, cilostazol, cisapride, colchicine, corticosteroids (eg, hydrocortisone), cyclosporine, digoxin, everolimus, fentanyl, HMG-CoA reductase inhibitors (eg, simvastatin), hydantoins (eg, phenytoin), lurasidone, macrolide antibiotics (eg, erythromycin ), macrolide immunosuppressants (eg, tacrolimus), nifedipine, quinidine, ranolazine, theophylline, or vasopressin antagonists (eg, tolvaptan) because the risk of their side effects, some potentially life-threatening, may be increased by Dilacor XR 24-Hour Sustained-Release Capsules


• Moricizine or rifamycins (eg, rifampin) because they may decrease Dilacor XR 24-Hour Sustained-Release Capsules's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dilacor XR 24-Hour Sustained-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dilacor XR 24-Hour Sustained-Release Capsules:

Use Dilacor XR 24-Hour Sustained-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Dilacor XR 24-Hour Sustained-Release Capsules by mouth on an empty stomach at least 1 hour before or 2 hours after eating.


• Swallow Dilacor XR 24-Hour Sustained-Release Capsules whole. Do not open, break, crush, or chew before swallowing.


• Taking Dilacor XR 24-Hour Sustained-Release Capsules at the same time each day will help you remember to take it.


• Continue to take Dilacor XR 24-Hour Sustained-Release Capsules even if you feel well. Do not miss any doses.


• If you miss a dose of Dilacor XR 24-Hour Sustained-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dilacor XR 24-Hour Sustained-Release Capsules.

Important safety information:

• Dilacor XR 24-Hour Sustained-Release Capsules may cause dizziness, lightheadedness, or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Dilacor XR 24-Hour Sustained-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Dilacor XR 24-Hour Sustained-Release Capsules may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Dilacor XR 24-Hour Sustained-Release Capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Dilacor XR 24-Hour Sustained-Release Capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• Do not suddenly stop taking Dilacor XR 24-Hour Sustained-Release Capsules. Your condition may get worse if you suddenly stop taking it. If you need to stop Dilacor XR 24-Hour Sustained-Release Capsules or add a new medicine, your doctor will gradually lower your dose.


• Tell your doctor or dentist that you take Dilacor XR 24-Hour Sustained-Release Capsules before you receive any medical or dental care, emergency care, or surgery.


• Be sure to have your blood pressure checked regularly while taking Dilacor XR 24-Hour Sustained-Release Capsules.


• Lab tests, including blood pressure, electrocardiogram (ECG), and heart rate, may be performed while you use Dilacor XR 24-Hour Sustained-Release Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Dilacor XR 24-Hour Sustained-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially swelling of the ankles, feet, or hands; dizziness; and slow heartbeat.


• Dilacor XR 24-Hour Sustained-Release Capsules should be used with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Dilacor XR 24-Hour Sustained-Release Capsules while you are pregnant. Dilacor XR 24-Hour Sustained-Release Capsules are found in breast milk. Do not breast-feed while taking Dilacor XR 24-Hour Sustained-Release Capsules.

Possible side effects of Dilacor XR 24-Hour Sustained-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; lightheadedness; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes; personality changes; reddened, blistered, or swollen skin; severe or persistent dizziness, lightheadedness, nausea, or vomiting; shortness of breath; sudden weight gain; swelling of the feet, ankles, or hands; symptoms of liver problems (eg, dark urine, pale stools, yellowing of the skin or eyes); tender, bleeding, or swollen gums; unusual bleeding or bruising; unusual or persistent tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Dilacor XR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; difficulty breathing, especially when lying down; dizziness; drowsiness; fainting; lightheadedness, especially when standing; loss of consciousness; nausea; nervousness; slurred speech; unusual weakness; very slow heart rate.

Proper storage of Dilacor XR 24-Hour Sustained-Release Capsules:

Store Dilacor XR 24-Hour Sustained-Release Capsules at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dilacor XR 24-Hour Sustained-Release Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Dilacor XR 24-Hour Sustained-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.


• Dilacor XR 24-Hour Sustained-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dilacor XR 24-Hour Sustained-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Dilacor XR resources

• Dilacor XR Side Effects (in more detail)
• Dilacor XR Use in Pregnancy & Breastfeeding
• Drug Images
• Dilacor XR Drug Interactions
• Dilacor XR Support Group
• 0 Reviews for Dilacor XR - Add your own review/rating

Compare Dilacor XR with other medications

• Angina Pectoris Prophylaxis
• Atrial Fibrillation
• Atrial Flutter
• Heart Failure
• High Blood Pressure
• Raynaud's Syndrome
• Supraventricular Tachycardia

Dimetapp DM

Generic Name: brompheniramine/dextromethorphan/phenylpropanolamine (brome fen IR a meen/dex troe meth OR fan/fen ill proe pa NOLE a meen)

Brand Names: Delhistine DM, Dimetapp Cold and Cough Liquigel, Dimetapp DM, DM Cold and Cough, Histinex DM, Iohist DM, Liquihistine DM, Poly DM, Poly Histine DM, Prohistine DM, Trihist DM

What is Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine)?

Brompheniramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body. Brompheniramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Dextromethorphan is a cough suppressant. It suppresses an area in the brain that causes coughing

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow, allowing nasal passages to open up.

Brompheniramine/dextromethorphan/phenylpropanolamine is used to treat nasal congestion, sinusitis (inflammation of the sinuses), and coughs associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Brompheniramine/dextromethorphan/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine)?

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Brompheniramine/dextromethorphan/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking brompheniramine/dextromethorphan/phenylpropanolamine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

Who should not take Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine)?

Do not take brompheniramine/dextromethorphan/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• kidney disease,


• liver disease,


• 
  

  diabetes,

  
  


• 
  

  glaucoma,

  
  


• 
  

  any type of heart disease or high blood pressure,

  
  


• 
  

  thyroid disease,

  
  


• 
  

  emphysema or chronic bronchitis, or

  
  


• 
  

  difficulty urinating or have an enlarged prostate.

  
  

You may not be able to take brompheniramine/dextromethorphan/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether brompheniramine/dextromethorphan/phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Brompheniramine/dextromethorphan/phenylpropanolamine passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from brompheniramine/dextromethorphan/phenylpropanolamine. You may require a lower dose of this medication. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

How should I take Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine)?

Take brompheniramine/dextromethorphan/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

To ensure that you get a correct dose, measure the liquid forms of brompheniramine/dextromethorphan/phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose of this medication can cause serious harm.

Do not take brompheniramine/dextromethorphan/phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store brompheniramine/dextromethorphan/phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a brompheniramine/dextromethorphan/phenylpropanolamine overdose include dry mouth, large pupils, flushing, nausea, vomiting, hyperactivity, or hallucinations.

What should I avoid while taking Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Brompheniramine/dextromethorphan/phenylpropanolamine may cause dizziness. If you experience dizziness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking brompheniramine/dextromethorphan/phenylpropanolamine.

Brompheniramine/dextromethorphan/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if brompheniramine/dextromethorphan/phenylpropanolamine is taken with any of these medications.

Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine) side effects

Serious side effects are unlikely to occur. Stop taking brompheniramine/dextromethorphan/phenylpropanolamine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take brompheniramine/dextromethorphan/phenylpropanolamine and talk to your doctor or try another similar medication if you experience

• 
  

  dryness of the eyes, nose, and mouth;

  
  


• 
  

  drowsiness or dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  difficulty urinating; or

  
  


• 
  

  excitation in children.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Dimetapp DM (brompheniramine/dextromethorphan/phenylpropanolamine)?

Do not take brompheniramine/dextromethorphan/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking brompheniramine/dextromethorphan/phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain brompheniramine, dextromethorphan, phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Brompheniramine/dextromethorphan/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if brompheniramine/dextromethorphan/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with brompheniramine/dextromethorphan/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Dimetapp DM resources

• Dimetapp DM Drug Interactions
• Dimetapp DM Support Group
• 0 Reviews for Dimetapp DM - Add your own review/rating

• Anaplex DMX Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Bromdex D Prescribing Information (FDA)


• Bromfed DM Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Bromfed DM Prescribing Information (FDA)


• Myphetane DX Prescribing Information (FDA)


• Neo DM Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Resperal-DM Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Dimetapp DM with other medications

• Cold Symptoms

Where can I get more information?

• Your pharmacist has additional information about brompheniramine/ dextromethorphan/phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Brompheniramine/dextromethorphan/phenylpropanolamine is available over the counter and with a prescription in many different formulations. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Dimetapp Cold & Cough

Generic Name: brompheniramine, dextromethorphan, and phenylephrine (brome fen IR a meen, dex troe metho OR fan, fen il EFF rin)

Brand Names: Alacol DM, Alahist DM, BP Allergy DM, BPM PE DM, Bromatan-DM, Bromtuss DM, BroveX PEB DM, Children's Cold & Cough DM, Cold & Cough Childrens, Dimaphen DM, Dimetapp Cold & Cough, Dimetapp DM Cold & Cough, DuraTan DM, Duravent DPB, Lohist-DM, Lortuss DM (obsolete), Tusdec-DM

What is Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Brompheniramine, dextromethorphan, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Brompheniramine, dextromethorphan, and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Brompheniramine, dextromethorphan, and phenylephrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

What should I discuss with my healthcare provider before taking Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking this medication, tell your doctor if you are allergic to brompheniramine, dextromethorphan, or phenylephrine, or if you have:

• kidney disease;


• liver disease;


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  diabetes;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  a stomach ulcer or a stomach obstruction,

  
  


• 
  

  emphysema or chronic bronchitis; or

  
  


• 
  

  an enlarged prostate or urination problems.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Brompheniramine, dextromethorphan, and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cough-and-cold medications may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

Use this medication exactly as directed on the label or as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Take this medicine with food or milk if it upsets your stomach.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store the medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

Avoid using other medicines that make you sleepy (such as sleeping pills, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine, dextromethorphan, and phenylephrine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  slow, shallow breathing;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, stomach pain, constipation;

  
  


• 
  

  mild loss of appetite, stomach upset;

  
  


• 
  

  warmth, tingling, or redness under your skin;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  restless or excitability (especially in children);

  
  


• 
  

  skin rash or itching;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration; or

  
  


• 
  

  ringing in your ears.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dimetapp Cold & Cough (brompheniramine, dextromethorphan, and phenylephrine)?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• 
  

  an antidepressant;

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  celecoxib (Celebrex);

  
  


• 
  

  cinacalcet (Sensipar);

  
  


• 
  

  darifenacin (Enablex);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  quinidine (Quinaglute, Quinidex);

  
  


• 
  

  ranolazine (Ranexa)

  
  


• 
  

  ritonavir (Norvir);

  
  


• 
  

  sibutramine (Meridia);

  
  


• 
  

  terbinafine (Lamisil);

  
  


• 
  

  medicines to treat high blood pressure;

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); or

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

  
  

This list is not complete and there may be other drugs that can interact with brompheniramine, dextromethorphan, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Dimetapp Cold & Cough resources

• Dimetapp Cold & Cough Side Effects (in more detail)
• Dimetapp Cold & Cough Use in Pregnancy & Breastfeeding
• Dimetapp Cold & Cough Drug Interactions
• 0 Reviews for Dimetapp Cold & Cough - Add your own review/rating

• Alacol DM Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Bromatan-DM Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Dimetapp Cold & Cough with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, dextromethorphan, and phenylephrine.

See also: Dimetapp Cold & Cough side effects (in more detail)

Dilantin

Generic Name: phenytoin (Oral route)

FEN-i-toin

Commonly used brand name(s)

In the U.S.

• Dilantin


• Dilantin-125


• Dilantin Infatabs


• Dilantin Kapseals


• Diphen


• Phenytek

In Canada

• Dilantin-30

Available Dosage Forms:

• Suspension


• Tablet, Chewable


• Capsule, Extended Release


• Capsule

Therapeutic Class: Anticonvulsant

Chemical Class: Hydantoin (class)

Uses For Dilantin

Phenytoin is used to control seizures (convulsions) in the treatment of epilepsy. It is also used to prevent and treat seizures that occur during brain surgery. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

This medicine is available only with your doctor's prescription.

Before Using Dilantin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of phenytoin in children.

Geriatric

No information is available on the relationship of age to the effects of phenytoin in geriatric patients. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving phenytoin.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Boceprevir


• Delavirdine


• Nifedipine


• Praziquantel


• Ranolazine


• Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abiraterone


• Apazone


• Beclamide


• Bortezomib


• Cabazitaxel


• Crizotinib


• Dasatinib


• Dronedarone


• Erlotinib


• Etravirine


• Everolimus


• Ezogabine


• Imatinib


• Infliximab


• Irinotecan


• Ixabepilone


• Ketorolac


• Lapatinib


• Lidocaine


• Linagliptin


• Lopinavir


• Maraviroc


• Methotrexate


• Naproxen


• Nilotinib


• Posaconazole


• Rivaroxaban


• Roflumilast


• Romidepsin


• St John's Wort


• Sunitinib


• Tacrolimus


• Temsirolimus


• Ticagrelor


• Tolvaptan


• Vandetanib


• Vemurafenib


• Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetaminophen


• Acetazolamide


• Acyclovir


• Amiodarone


• Amitriptyline


• Amprenavir


• Aprepitant


• Atorvastatin


• Betamethasone


• Bexarotene


• Bleomycin


• Busulfan


• Capecitabine


• Carbamazepine


• Carboplatin


• Caspofungin


• Chloramphenicol


• Cimetidine


• Ciprofloxacin


• Cisplatin


• Clarithromycin


• Clobazam


• Clofazimine


• Clopidogrel


• Clozapine


• Colesevelam


• Cortisone


• Cyclosporine


• Desogestrel


• Dexamethasone


• Diazepam


• Dicumarol


• Dienogest


• Digitoxin


• Diltiazem


• Disopyramide


• Disulfiram


• Doxepin


• Doxorubicin Hydrochloride


• Drospirenone


• Estradiol Cypionate


• Estradiol Valerate


• Ethinyl Estradiol


• Ethosuximide


• Ethynodiol Diacetate


• Etonogestrel


• Felbamate


• Fentanyl


• Fluconazole


• Fludrocortisone


• Fluorouracil


• Fluoxetine


• Fluvoxamine


• Folic Acid


• Fosamprenavir


• Gefitinib


• Ginkgo


• Ibuprofen


• Imipramine


• Isoniazid


• Itraconazole


• Levodopa


• Levomethadyl


• Levonorgestrel


• Levothyroxine


• Medroxyprogesterone Acetate


• Meperidine


• Mestranol


• Methoxsalen


• Methsuximide


• Miconazole


• Midazolam


• Nafimidone


• Nelfinavir


• Nilutamide


• Nisoldipine


• Norelgestromin


• Norethindrone


• Norgestimate


• Norgestrel


• Oxcarbazepine


• Paclitaxel


• Pancuronium


• Paroxetine


• Phenprocoumon


• Piperine


• Prednisolone


• Prednisone


• Progabide


• Quetiapine


• Quinidine


• Quinine


• Remacemide


• Rifampin


• Rifapentine


• Risperidone


• Ritonavir


• Rufinamide


• Sabeluzole


• Sertraline


• Shankhapulshpi


• Simvastatin


• Sirolimus


• Sulfamethizole


• Sulfaphenazole


• Sulthiame


• Telithromycin


• Tenidap


• Theophylline


• Tiagabine


• Ticlopidine


• Ticrynafen


• Tirilazad


• Tizanidine


• Tolbutamide


• Topiramate


• Trazodone


• Triamcinolone


• Trimethoprim


• Tubocurarine


• Valproic Acid


• Vecuronium


• Verapamil


• Vigabatrin


• Viloxazine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Enteral Nutrition


• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone problems (e.g., osteomalacia) or


• Depression, history of or


• Diabetes or


• Lymphadenopathy (lymph node problems) or


• Porphyria (an enzyme problem)—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal from the body.

Proper Use of phenytoin

This section provides information on the proper use of a number of products that contain phenytoin. It may not be specific to Dilantin. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine may be used with other seizure medicines. Keep using all of your seizure medicines unless your doctor tells you to stop.

Do not change brands or dosage forms of phenytoin without first checking with your doctor. Different products may not work the same way. If you refill your medicine and it looks different, check with your pharmacist.

Swallow the tablet whole or chew it thoroughly before being swallowed together with a glass of water.

Measure the oral suspension with a marked measuring spoon, oral syringe, or medicine cup. Rinse the dosing spoon or cup with water after each use.

If you are receiving tube feeding preparations, it is best to take this medicine before or after a feeding.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For seizures:
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 100 milligrams (mg) three times a day or 300 mg once a day. Your doctor may increase your dose as needed. For patients in the clinic or hospital (except with a history of liver or kidney disease), a loading dose of 1000 mg is divided into three doses (400 mg, 300 mg, 300 mg) and given every two hours. Then, normal maintenance dose may be started 24 hours after the loading dose.
    
    
    • Teenagers and children above 6 years of age—300 mg per day. Your doctor may increase your dose as needed.
    
    
    • Children 6 years of age and below—Dose is based on body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) of body weight given in two or three divided doses per day. The doctor may adjust the dose as needed.
    
    
  
  
  • For oral dosage form (suspension):
    
    • Adults—At first, 5 milliliters (mL) or 125 milligrams (mg) three times a day. Your doctor may increase your dose as needed.
    
    
    • Teenagers and children above 6 years of age—300 milligrams (mg) per day. Your doctor may increase your dose as needed.
    
    
    • Children 6 years of age and below—Dose is based on age and body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) of body weight given in two or three divided doses per day. Your doctor may adjust your dose as needed.
    
    
  
  
  • For oral dosage form (tablets):
    
    • Adults—At first, 100 milligrams (mg) three times a day. Your doctor may increase your dose as needed.
    
    
    • Teenagers and children above 6 years of age—300 milligrams (mg) per day, given in two or three divided doses per day. Your doctor may increase your dose as needed.
    
    
    • Children 6 years of age and below—Dose is based on age and body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) of body weight given in two or three divided doses per day. The doctor may adjust the dose as needed.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Dilantin

It is very important that your doctor check your progress at regular visits while you are using this medicine to see if it is working properly and to allow for a change in the dose. Blood tests may be needed to check for any unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Your doctor may want you to join a pregnancy registry for patients taking a seizure medicine.

Lymph node problems may occur while using this medicine. Check with your doctor right away if you have swollen, painful, or tender lymph glands in your neck, armpit, or groin.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely.

If you develop a skin rash, hives, or any allergic reaction to this medicine, stop taking the medicine and check with your doctor as soon as possible.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away.

In some patients (usually younger patients), tenderness, swelling, or bleeding of the gums (gingival hyperplasia) may appear soon after phenytoin treatment is started. To help prevent this, brush and floss your teeth carefully and regularly and massage your gums. Also, see your dentist every 6 months to have your teeth cleaned. If you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums, check with your doctor or dentist.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Avoid drinking alcohol while you are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Dilantin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Decreased coordination


• mental confusion


• nervousness


• slurred speech


• trouble with breathing, speaking, or swallowing


• unsteadiness, trembling, or other problems with muscle control or coordination

Rare

• Inability to move the eyes


• increased blinking or spasms of the eyelid


• shakiness and unsteady walk shakiness in the legs, arms, hands, or feet


• sticking out of the tongue


• trembling or shaking of the hands or feet


• twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs


• uncontrolled twisting movements of the neck, trunk, arms, or legs


• unusual facial expressions

Incidence not known

• Abdominal or stomach pain


• bleeding gums


• blistering, peeling, or loosening of the skin


• blisters, hives, or itching


• bloating of the abdomen or stomach


• blood in the urine or stools


• bloody, black, or tarry stools


• chest pain


• chills


• cough or hoarseness


• dark urine


• diarrhea


• difficulty with moving


• fainting spells


• fever with or without chills


• general feeling of discomfort or illness


• general feeling of tiredness or weakness


• hair loss


• headache


• high fever


• irregular heartbeat


• irritation in the mouth


• joint or muscle pain


• light-colored stools


• lower back or side pain


• muscle stiffness


• nausea or vomiting


• numbness, tingling, or pain in the hands or feet


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• red skin lesions, often with a purple center


• red, irritated eyes


• redness and swelling of the gums


• shortness of breath or troubled breathing


• skin blisters


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• swollen, painful, or tender lymph glands in the neck, armpit, or groin


• unexplained bleeding or bruising


• unusual bleeding or bruising


• unusual tiredness


• upper right abdominal pain


• weakness


• weight loss


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Sleeplessness


• trouble with sleeping


• unable to sleep


• uncontrolled eye movements

Incidence not known

• Difficulty having a bowel movement (stool)


• enlarged lips


• increased hair growth on the forehead, back, arms, or legs


• pain of penis on erection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Dilantin side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Dilantin resources

• Dilantin Side Effects (in more detail)
• Dilantin Use in Pregnancy & Breastfeeding
• Drug Images
• Dilantin Drug Interactions
• Dilantin Support Group
• 38 Reviews for Dilantin - Add your own review/rating

• Dilantin Prescribing Information (FDA)


• Dilantin Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Dilantin Consumer Overview


• Phenytoin Professional Patient Advice (Wolters Kluwer)


• Phenytoin Monograph (AHFS DI)


• Phenytoin MedFacts Consumer Leaflet (Wolters Kluwer)


• Dilantin Infatabs Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Dilantin Infatabs Prescribing Information (FDA)


• Dilantin Kapseals Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Dilantin Kapseals Prescribing Information (FDA)


• Dilantin-125 Prescribing Information (FDA)


• Phenytek Prescribing Information (FDA)

Compare Dilantin with other medications

• Anxiety
• Arrhythmia
• Epilepsy
• Neurosurgery
• Peripheral Neuropathy
• Seizures
• Status Epilepticus
• Trigeminal Neuralgia

Dilantin Suspension

Pronunciation: FEN-i-toin
Generic Name: Phenytoin
Brand Name: Dilantin

Dilantin Suspension is used for:

Treating tonic-clonic (grand mal) and partial seizures. It is also used to prevent and treat seizures that may occur during or after brain or nervous system surgery. It may also be used for other conditions as determined by your doctor.

Dilantin Suspension is an anticonvulsant. It works in the brain to block the spread of seizure activity.

Do NOT use Dilantin Suspension if:

• you are allergic to any ingredient in Dilantin Suspension or to another hydantoin (eg, fosphenytoin)


• you are taking cabazitaxel, crizotinib, dronedarone, etravirine, lurasidone, nifedipine, nisoldipine, praziquantel, ranolazine, rilpivirine, rivaroxaban, roflumilast, ticagrelor, or vandetanib

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dilantin Suspension:

Some medical conditions may interact with Dilantin Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have the blood disease porphyria, liver disease, diabetes, a weakened immune system, bone problems (eg, weak bones, osteoporosis), or a history of lymph gland problems


• if you or a family member has had anticonvulsant hypersensitivity syndrome (AHS)


• if you are in very poor health or you receive nutrition through an enteral tube (eg, G-tube)


• if you drink alcohol or have a history of alcohol abuse


• if you have been tested and know whether or not you have a gene type called HLA-B*1502


• if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or attempts

Some MEDICINES MAY INTERACT with Dilantin Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Many other prescription and nonprescription medicines (eg, used for allergic reactions, asthma or other breathing problems, blood thinning, diabetes, infections, inflammation, aches and pains, attention deficit hyperactivity disorder, alcoholism, cancer, high blood pressure, indigestion, irregular heartbeat or other heart problems, hepatitis C, high blood iron levels, high cholesterol, HIV, birth control, hormone replacement, immune system suppression, mental or mood problems, pain, sleep, seizures, stomach or bowel problems), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with Dilantin Suspension. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Dilantin Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dilantin Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dilantin Suspension:

Use Dilantin Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Dilantin Suspension comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Dilantin Suspension refilled.


• Take Dilantin Suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Shake well before each use. Be sure the medicine is completely mixed before you take a dose.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you take a calcium product (eg, certain antacids), colesevelam, or molindone, ask your doctor or pharmacist how to take it with Dilantin Suspension.


• Do not suddenly stop taking Dilantin Suspension. You may have an increased risk of seizures if you stop taking it. If you need to stop Dilantin Suspension, your doctor will gradually lower your dose.


• Continue to take Dilantin Suspension even if you feel well. Do not miss any doses.


• Taking Dilantin Suspension at the same time each day will help you remember to take it.


• If you miss a dose of Dilantin Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dilantin Suspension.

Important safety information:

• Dilantin Suspension may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Dilantin Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you drink alcohol while you are taking Dilantin Suspension. Alcohol may increase or decrease the amount of medicine in your blood.


• Do not change brands or doseforms (eg, tablets, capsules, injection) of Dilantin Suspension without talking with your doctor.


• Do NOT take more than the recommended dose or change your dose without checking with your doctor.


• Patients who take Dilantin Suspension may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Dilantin Suspension closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Proper dental care is important while you are taking Dilantin Suspension. Brush and floss your teeth and visit the dentist regularly.


• Dilantin Suspension may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• There have been reports of lymph node problems, including cancer, in patients who take Dilantin Suspension. It is not known if Dilantin Suspension may be the cause. Contact your doctor right away if you develop swollen lymph nodes.


• Rarely, a serious and sometimes fatal effect (AHS) has occurred in patients who take Dilantin Suspension. The risk may be higher in black patients and in patients with a weakened immune system. It may also be higher if a patient or family member has had AHS in the past. If this effect occurs, it usually happens within 2 to 4 weeks of starting treatment. However, it has also occurred in patients who have been taking Dilantin Suspension for 3 months or more. Contact your doctor right away if you develop swollen lymph nodes, fever, rash, or symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, stomach pain, yellowing of the skin or eyes).


• Long-term treatment with Dilantin Suspension may cause low blood vitamin D levels. This may increase the risk of low blood calcium or phosphate levels. It may also increase the risk of bone softening, weak bones, or other bone problems (eg, fractures). Discuss any questions or concerns with your doctor.


• Tell your doctor or dentist that you take Dilantin Suspension before you receive any medical or dental care, emergency care, or surgery.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Dilantin Suspension. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Patients who have a certain gene type called HLA-B*1502 may have an increased risk of serious skin reactions from Dilantin Suspension. This gene type is found most commonly in Asian patients. Tell your doctor if you have been tested and know whether or not you have the HLA-B*1502 gene type. Discuss any questions or concerns with your doctor.


• Dilantin Suspension may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Dilantin Suspension.


• Lab tests, including blood phenytoin levels or liver function, may be performed while you use Dilantin Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Dilantin Suspension with caution in the ELDERLY; they may be more sensitive to its effects.


• Women who take Dilantin Suspension may experience an increase in seizure activity if they become pregnant. Discuss any questions or concerns with your doctor. If you think you may be pregnant, contact your doctor.


• Dilantin Suspension may cause harm to the fetus. If you may become pregnant, discuss other possible treatment options with your doctor. If a decision is made to take Dilantin Suspension, use effective birth control while you are taking it. Talk with your doctor if you are planning to become pregnant, or if you have questions or concerns about this information.


• PREGNANCY and BREAST-FEEDING: Dilantin Suspension may cause harm to the fetus. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of taking Dilantin Suspension while you are pregnant. You and your doctor will need to decide if you will continue to take Dilantin Suspension while you are pregnant. Dilantin Suspension is found in breast milk. Do not breast-feed while taking Dilantin Suspension.

Possible side effects of Dilantin Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; headache; mild nervousness; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, eyes, face, lips, or tongue); bone pain; burning, numbness, or tingling; butterfly-shaped rash on the face; clumsiness or unsteadiness; confusion; delirium; new or worsening mental or mood changes (eg, agitation, anxiety, behavior changes, depression, irritability, panic attacks, restlessness, suicidal thoughts or attempts); new or worsening seizures; red, swollen, blistered, or peeling skin; severe muscle pain; severe or persistent trouble sleeping; signs of infection (eg, chills, fever, sore throat); slurred speech; sores in the mouth or around the eyes; swollen lymph nodes; swollen or tender gums; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, stomach pain, yellowing of the skin or eyes); tremor; trouble walking; unusual bruising or bleeding; unusual eye movements; unusual muscle movements; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Dilantin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; decreased coordination; fainting; loss of consciousness; severe dizziness or drowsiness; severe or persistent nausea or vomiting; slow or difficult breathing; sluggishness; speech problems (eg, slurred speech); tremor; unusual eye movements.

Proper storage of Dilantin Suspension:

Store Dilantin Suspension at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dilantin Suspension out of the reach of children and away from pets.

General information:

If you have any questions about Dilantin Suspension, please talk with your doctor, pharmacist, or other health care provider.

• If you have any questions about Dilantin Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Dilantin Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dilantin Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Dilantin resources

• Dilantin Side Effects (in more detail)
• Dilantin Use in Pregnancy & Breastfeeding
• Drug Images
• Dilantin Drug Interactions
• Dilantin Support Group
• 38 Reviews for Dilantin - Add your own review/rating

Compare Dilantin with other medications

• Anxiety
• Arrhythmia
• Epilepsy
• Neurosurgery
• Peripheral Neuropathy
• Seizures
• Status Epilepticus
• Trigeminal Neuralgia